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KMID : 0380620130450020199
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Korean Journal of Food Science and Technology
2013 Volume.45 No. 2 p.199 ~ p.205
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Anti-obesity Effects of Ishige okamurae Extract in C57BL/6J mice Fed High-fat Diet
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Park Se-Jin
Jeon You-Jin
Kim Hak-Ju
Han Ji-Sook
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Abstract
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We investigated the anti-obesity effects of Ishige okamurae extract (IOE) on body weight, epididymal adipose tissue weight, plasma lipid levels, and leptin levels in high-fat diet (HFD)-induced obese mice. After inducing obesity by feeding 45% HFD for 4 weeks, C57BL/6J mice were randomly assigned to HFD or HFD containing 5% IOE, and then fed for 6 weeks. The body weight and epididymal adipose tissue weight were increased by HFD, but they were significantly less in animals fed HFD containing 5% IOE than in those fed HFD. Levels of plasma triglyceride, total cholesterol, and LDL-cholesterol were significantly lower, but the HDL-cholesterol level was significantly higher in animals fed HFD containing 5% IOE compared with the HFD group. The plasma leptin level was significantly lower in animals fed HFD containing 5% IOE. The diet containing 5% IOE did not show any adverse effects on liver and kidney functions. These results suggest that IOE has a potential as anti-obesity agent by reducing body weight and lowering the levels of obesity-related factors in plasma.
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KEYWORD
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Ishige okamurae, anti-obesity, high-fat diet, C57BL/6J mice
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